Expression of CA125 in tissue and serum of uterine serous carcinoma patients
نویسندگان
چکیده
Uterine serous carcinoma (USC) represents only about 10% of endometrial cancer cases. It is an aggressive tumor with a poor prognosis that is diagnosed in advanced stages in about 40% of the cases and it accounts for a disproportionate number of uterine cancer-related deaths. Even in apparent clinical early stage disease, USC is found to have unfavorable pathological prognostic factors such as lymphovascular space invasion, lymph node involvement, and microscopic intraperitoneal spread [1,2].
منابع مشابه
طبقهبندی مجدد کارسینوماهای سروز تخمدان با روش جدید تقسیمبندی دوگانه (two-tier) و بررسی بروز ژن P53 با رنگآمیزی ایمونوهیستوشیمی
Background: Recently the use of “two tier" grading system in which ovarian serous carcinoma was classified as low-grade or high-grade in comparing to preceding system has improved authority in prognosis and survival. This approach is simplistic, reproducible, and based on biologic evidence. In this study, we reclassified ovarian serous carcinoma by a new two-tier system for grading and then eva...
متن کاملPrognostic Values of Estrogen and Progesterone Expression Receptors in Ovarian Papillary Serous Carcinoma
Background and Objectives: Presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. Since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic value of the estrogen receptor (ER) and progesterone receptors (PR) in ovarian papillary ser...
متن کاملPrevalence of K-RAS mutations and CA125 tumor marker in patients with ovarian carcinoma
Background: Ovarian carcinoma is one of the leading causes of cancer-related death among females. K-ras codon 12 mutations are commonly occurring mutations in different types of cancers and leads to resistance against anti-EGFR therapeutics. Hence, determination of mutations in k-ras gene is crucial for predicting response to anti-EGFR therapies. This study aimed to evaluate the prevalence of k...
متن کاملCA125 expression in the tissue of uterine leiomyosarcoma.
UNLABELLED Background: Elevated serum levels of the epithelial marker CA125 are occasionally observed in leiomyosarcoma (LMS) patients. OBJECTIVES To assess the immunohistochemical expression of this marker in the tissue of LMS. METHODS The consecutive unselected records of all patients with LMS diagnosed during the period 1995-2012 were located and abstracted. After verification of the dia...
متن کاملHigh levels of pretreatment CA125 are associated to improved survival in high grade serous ovarian carcinoma
BACKGROUND Serum levels of CA125 measured before any treatment have been evaluated in epithelial ovarian cancer (EOC) as a predictor of patient survival; however, results in survival index are controversial, as CA125 levels are influenced by several variables. Taking this into consideration, the present study evaluated the association of pretreatment levels of CA125 serum with the clinical stag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015